SubtiBank SubtiBank
divIC [Mon Aug 31 2015 13:51:49 GMT+0200 (CEST)]
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divIC [Mon Aug 31 2015 13:51:49 GMT+0200 (CEST)]

cell-division initiation protein (septum formation), component of septosome (with DivIB)
locus
BSU00620
pI
9.97
mw
14.00 kDa
function
septum formation
product
cell-division protein
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|cell division], [SW|sporulation proteins], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon], [SW|SigM regulon], [SW|SigW regulon], [SW|SigX regulon]
  • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • stabilizes [protein|search|FtsL] against [protein|search|RasP] cleavage [Pubmed|20644139]
  • [SW|Localization]

  • membrane bound [Pubmed|9426141]
  • [SW|Interactions]

  • [SW|DivIC]-[protein|search|FtsL] [Pubmed|10844672]
  • [protein|search|PbpB]-[SW|DivIB]-([protein|search|FtsL]-[SW|DivIC])2 [Pubmed|20870765], as part of the [SW|divisome]
  • Expression and Regulation

    Operon

  • ''[protein|search|yabM]-[protein|search|yabN]-[protein|search|yabO]-[protein|search|yabP]-[protein|search|yabQ]-[SW|divIC]-[protein|search|yabR]'' [Pubmed|11283287]
  • ''[protein|search|yabP]-[protein|search|yabQ]-[SW|divIC]-[protein|search|yabR]'' [Pubmed|11283287]
  • ''[SW|divIC]-[protein|search|yabR]'' [Pubmed|11283287]
  • [SW|Sigma factor]

  • ''[protein|search|yabM]'': unknown
  • ''[protein|search|yabP]'': [protein|search|SigE] [Pubmed|11283287]
  • ''[SW|divIC]'': [protein|search|SigM] [Pubmed|18179421], [protein|search|SigX] [Pubmed|12207695], [protein|search|SigW] [Pubmed|12207695]
  • Regulation

  • expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287] and under stress conditions
  • Biological materials

    FLAG-tag construct

  • GP2006 ''divIC-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab
  • References

  • 18179421,16936019,10217758,9720875,8113187,10323866,9426141,10852898,10844672,11283287,11994149,20870765,25176632,20644139