repressor of fatty acid synthetic genes
function
regulation of fatty acid biosynthesis
product
transcriptional repressor
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|ComA regulon], [SW|FapR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,661,967 -> 1,662,533
The protein
Catalyzed reaction/ biological activity
FapR regulates the expression of at least 10 genes (the ''fap'' regulon). It autoregulates its own expression. Malonyl-CoA, a precursor of fatty acid biosynthesis, binds to FapR changing its conformation to a non-DNA binding state. Hence, conditions that cause malonyl-CoA accumulation, like fatty acid biosynthesis inhibition, derepress the ''fap'' regulon.Protein family
fapR family (according to Swiss-Prot)Effectors of protein activity
malonyl-CoA and malonyl-[AcpA|search|ACP] act as the molecular inducer of the FapR regulon [Pubmed|20201588]Structure
[PDB|2F3X] (complex with effector), [PDB|2F41][SW|Interactions]
malonyl-[AcpA|search|ACP]-[protein|search|FapR] [Pubmed|20201588]Expression and Regulation
Operon
''[protein|search|fapR]-[protein|search|plsX]-[protein|search|fabD]-[protein|search|fabG]-[protein|search|acpA]'' [Pubmed|12737802,19850612][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16932747]Regulation
repressed in the absence of malonyl-CoA or malonyl-[AcpA|search|ACP] ([protein|search|FapR]) [Pubmed|20201588]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|FapR]: transcription repression [Pubmed|12737802]Biological materials
Mutant
MGNA-B138 (ylpC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1137 NBRP B. subtilis, Japan]References
Reviews
The [SW|FapR regulon]
