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kduD [2017-05-19 09:23:14]
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kduD [2017-05-19 09:23:14]

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
locus
BSU22140
pI
6.50
mw
27.04 kDa
protein length
254 aa Sequence Blast
gene length
762 bp Sequence Blast
function
utilization of galacturonic acid
essential
no
ec
1.1.1.125
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]
  • Gene

    Coordinates
    2,326,683 → 2,327,447

    The protein

    Catalyzed reaction/ biological activity

  • 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH (according to Swiss-Prot)
  • Protein family

  • phosphopentomutase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|B6FF689E65906186F3576B378650D713DB84EDDA|YcdF], [protein|3161519994609DA9360ED6E073E4A4C8C6210EFB|YdaD], [protein|EAEEA4DD9641919830A81185333A2610B964D37C|YhdF]
  • Structure

  • [PDB|4HP8] (from Agrobacterium tumefaciens, 54% identity)
  • Expression and Regulation

    Operons

    genes
    [gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]-[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]
    description
    [Pubmed|17322190]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17322190], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|891A32A19D1353BA566FF121BBCA7B986D31D129|KdgR]: repression, [Pubmed|17322190], in [regulon|891A32A19D1353BA566FF121BBCA7B986D31D129|KdgR regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|17322190], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • regulation

  • induced by galacturonate ([protein|search|KdgR]) [Pubmed|17322190]
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    References

  • 17322190