kduD [Mon Aug 31 2015 13:55:13 GMT+0200 (CEST)]

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

locus: BSU22140

pI: 6.50

mw: 27.00 kDa

function: utilization of galacturonic acid

essential: no

ec: 1.1.1.125

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|KdgR regulon]

The protein

Catalyzed reaction/ biological activity

• 2-deoxy-D-gluconate + NAD⁺ = 3-dehydro-2-deoxy-D-gluconate + NADH (according to Swiss-Prot)

Protein family

• phosphopentomutase family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|kduI]-[protein|search|kduD]'' [Pubmed|17322190]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|17322190]

Regulation

• induced by galacturonate ([protein|search|KdgR]) [Pubmed|17322190]
• repressed by glucose ([protein|search|CcpA]) [Pubmed|17322190]

Regulatory mechanism

• [protein|search|KdgR]: transcription repression [Pubmed|17322190]
• [protein|search|CcpA]: transcription repression [Pubmed|17322190]

References

• 17322190