hutG [Fri Nov 13 2015 16:48:15 GMT+0100 (CET)]

formiminoglutamate hydrolase

locus: BSU39380

pI: 5.00

mw: 34.00 kDa

function: histidine utilization

product: formiminoglutamate hydrolase

essential: no

ec: 3.5.3.8

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine]

[SW|Categories] containing this gene/protein

• [SW|utilization of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]

Gene

Coordinates on the chromosome (coding sequence): 4,046,503 -> 4,047,462

The protein

Catalyzed reaction/ biological activity

• N-formimidoyl-L-glutamate H₂O = L-glutamate formamide (according to Swiss-Prot)

Protein family

• arginase family (according to Swiss-Prot)

Structure

• [http://pdb.org/pdb/explore/explore.do?structureId=3M1R 3M1R]

Expression and Regulation

Operon

• ''[protein|search|hutP]-[protein|search|hutH]-[protein|search|hutU]-[protein|search|hutI]-[protein|search|hutG]-[protein|search|hutM]'' [Pubmed|10746760]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8071225]

Regulation

• repressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]
• induced by histidine ([protein|search|HutP]) [Pubmed|8071225]
• repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]

Regulatory mechanism

• [protein|search|CcpA]: transcription repression [Pubmed|8071225]
• [protein|search|CodY]: transcription repression [Pubmed|8682780]
• [protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]

References

Reviews

• 22933560

Original publications

• 10746760,8682780,10217782,8071225