nadA [Tue Dec 29 2015 18:02:51 GMT+0100 (CET)]

quinolinate synthetase

locus: BSU27850

pI: 5.00

mw: 41.00 kDa

function: NAD biosynthesis

product: quinolinate synthetase

essential: no

ec: 2.5.1.72

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|NadR regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,845,955 -> 2,847,061

The protein

Catalyzed reaction/ biological activity

• Glycerone phosphate iminosuccinate = pyridine-2,3-dicarboxylate 2 H₂O phosphate (according to Swiss-Prot)

Protein family

• Type 3 subfamily (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|nadB]-[protein|search|nadC]-[protein|search|nadA]'' [Pubmed|8444804]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8444804]

Regulation

• repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|16199587]

Regulatory mechanism

• [protein|search|NadR]: transcription repression [Pubmed|16199587]

Labs working on this gene/protein

• [SW|Alessandra Albertini], University of Pavia, Italy [http://www-1.unipv.it/genbiom/albertini.html homepage]

References

• 18959769,16199587,8444804