lysC [2017-8-11 16:0:3]

aspartokinase II (alpha and beta subunits)

locus: BSU28470

pI: 4.64

mw: 43.65 kDa

protein length: 408 aa

gene length: 1224 bp

function: biosynthesis of lysine

product: aspartokinase II (alpha and beta subunits)

essential: no

ec: 2.7.2.4

synonyms: ask, aecA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]

Gene

Coordinates: 2,909,520 → 2,910,746

The protein

Catalyzed reaction/ biological activity

• ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)

Protein family

• aspartokinase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|DapG]

Structure

• [PDB|2RE1] (from ''Neisseria meningitidis mc58'', 40% identity, 58% similarity)

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983], also degraded upon ammonium or amino acid starvation [Pubmed|2168395]
• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

Expression and Regulation

Operons

• genes: [gene|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC]
  description: [Pubmed|19636616]

  regulatory mechanism

  • [regulon|L-box|L-box]: transcription termination/antitermination, via a riboswitch, in [regulon|L-box|L-box]

  regulation

  • expression activated by glucose (5.4 fold) [Pubmed|12850135]

References

Reviews

• 19946135,22079167

=The [SW|L-box]] [[riboswitch]=

• 14523230,14597663,19636616,21169337,22416067,23067368