SubtiBank SubtiBank
lysC [Mon May 16 2016 16:00:14 GMT+0200 (CEST)]
Save the date! 20th International Conference on Bacilli and Gram-Positive Bacteria. Washington, D.C. July 23-26, 2019.

lysC [Mon May 16 2016 16:00:14 GMT+0200 (CEST)]

aspartokinase II (alpha and beta subunits)
locus
BSU28470
pI
4.00
mw
43.00 kDa
function
biosynthesis of lysine
product
aspartokinase II (alpha and beta subunits)
essential
no
ec
2.7.2.4
synonyms
ask, aecA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|L-box]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,909,520 -> 2,910,746

    The protein

    Catalyzed reaction/ biological activity

  • ATP L-aspartate = ADP 4-phospho-L-aspartate (according to Swiss-Prot)
  • Protein family

  • aspartokinase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|DapG]
  • Structure

  • [PDB|2RE1] (from ''Neisseria meningitidis mc58'', 40% identity, 58% similarity)
  • Additional information

  • :
  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed], also degraded upon ammonium or amino acid starvation [Pubmed|2168395]
  • Expression and Regulation

    Operon

  • ''lysC'' [Pubmed|19636616]
  • Regulation

  • repressed in the presence of lysine ([protein|search|L-box]) [Pubmed|19636616]
  • expression activated by glucose (5.4 fold) [Pubmed|12850135]
  • repressed by casamino acids [Pubmed|12107147]
  • Regulatory mechanism

  • [protein|search|L-box]: a riboswich that mediates transcription terimnation antitermination control [Pubmed|19636616]
  • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed], also degraded upon ammonium or amino acid starvation [http://www.ncbi.nlm.nih.gov/sites/entrez/2168395 PubMed]
  • belongs to the 100 [[most abundant proteins]] [PubMed|15378759]
  • References

    Reviews

  • 19946135,22079167
  • =The [SW|L-box]] [[riboswitch]=

  • 14523230,14597663,19636616,21169337,22416067,23067368