SubtiBank SubtiBank
dacF [Tue Feb 23 2016 19:11:04 GMT+0100 (CET)]
SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

dacF [Tue Feb 23 2016 19:11:04 GMT+0100 (CET)]

penicillin-binding protein I, D-alanyl-D-alanine carboxypeptidase
locus
BSU23480
pI
9.00
mw
43.00 kDa
function
carboxypeptidase
product
penicillin-binding protein I,
D-alanyl-D-alanine carboxypeptidase
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|sporulation proteins], [SW|penicillin-binding proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigF regulon], [SW|SigG regulon], [SW|AbrB regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,445,094 -> 2,446,263

    The protein

    Catalyzed reaction/ biological activity

  • modifies degree of cross-linking of glycan strands in peptidoglycan
  • Protein family

  • peptidase S11 family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|DacA]
  • Expression and Regulation

    Operon

  • ''[protein|search|dacF]-[SW|spoIIAA]-[SW|spoIIAB]-[protein|search|sigF]'' [Pubmed|22383849]
  • [SW|Sigma factor]

  • [protein|search|SigF] [Pubmed|15699190], [protein|search|SigG]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • expressed during sporulation in the forespore [Pubmed|15758244]
  • Regulatory mechanism

  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]
  • References

  • 16497325,8936302,9864321,12107147,20817675,22123250