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gcvT [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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gcvT [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

aminomethyltransferase (glycine cleavage system protein T)
locus
BSU24570
pI
5.73
mw
39.00 kDa
function
glycine utilization
product
aminomethyltransferase
(glycine cleavage system protein T)
essential
no
ec
2.1.2.10
synonyms
yqhI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.8|Utilization of threonine/ glycine]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|Gly-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,548,245 -> 2,549,333

    The protein

    Catalyzed reaction/ biological activity

  • [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3 (according to Swiss-Prot)

    • Protein family

  • gcvT family (according to Swiss-Prot)

    • [SW|Cofactors]

  • tetrahydrofolate

    • Structure

  • [PDB|1YX2]

    • Expression and Regulation

    Operon

  • '' [protein|search|gcvT]-[SW|gcvPA]-[SW|gcvPB]'' [Pubmed|15472076]

    • Regulation

  • induced by glycine [Pubmed|15472076]

    • Regulatory mechanism

  • induction requires a co-operatively acting [SW|riboswitch] ([protein|search|Gly-box]) [Pubmed|15472076]

    • Biological materials

    lacZ fusion

  • pGP431 (in [protein|search|pAC7]), available in [SW|Stülke] lab

    • References

  • 15096624,15472076,23249744,23721735