yxdK [2017-8-11 16:0:3]

two-component sensor kinase, regulation of the ABC transporter YxdL-YxdM in response to the cationic antimicrobial peptide, LL-37

locus: BSU39650

pI: 6.23

mw: 37.83 kDa

protein length: 325 aa

gene length: 975 bp

function: resistance against toxic peptides

product: two-component sensor kinase

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

Gene

Coordinates: 4,071,310 → 4,072,287

Phenotypes of a mutant

• defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]

The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|F3C5505E311E6DDABAFA87899F28CF6596CDBA63|YxdJ]

[SW|Domains]

• two transmembrane segments, C-terminal histidine phosphotransferase domain

Modification

• autophosphorylation on a His residue

Expression and Regulation

Operons

• genes: [gene|F3C5505E311E6DDABAFA87899F28CF6596CDBA63|yxdJ]-[gene|F5BB96607452AC38ECF66923DB8758C364FE2F46|yxdK]
  description: [Pubmed|10746760]

Biological materials

Mutant

• MGNA-B804 (yxdK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1803 NBRP B. subtilis, Japan]

References

• 10094672,10746760,17600057,21283517,21078927,25875741