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epr [Wed Jun 15 2016 16:34:42 GMT+0200 (CEST)]
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epr [Wed Jun 15 2016 16:34:42 GMT+0200 (CEST)]

minor extracellular serine protease, involved in control of swarming motility
locus
BSU38400
pI
9.00
mw
69.00 kDa
function
protein degradation
product
minor extracellular serine protease
essential
no
synonyms
ipa-15r
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.5|Utilization of proteins]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.2|Extracellular feeding proteases]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of nitrogen sources other than amino acids], [SW|proteolysis], [SW|motility and chemotaxis]

    • This gene is a member of the following [SW|regulons]

  • [SW|DegU regulon], [SW|ScoC regulon], [SW|SigD regulon], [SW|SinR regulon], [SW|Spo0A regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,939,869 -> 3,941,806

    The protein

    Protein family

  • peptidase S8 family (according to Swiss-Prot)

    • [SW|Localization]

  • extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operon

  • ''[protein|search|epr]'' [Pubmed|3142851]

    • [SW|Sigma factor]

  • [protein|search|SigD] [Pubmed|11751842]

    • Regulation

  • repressed by [protein|search|SinR] [Pubmed|16923912]
  • repressed during exponential growth ([protein|search|ScoC]) [Pubmed|16923912]

    • Regulatory mechanism

  • activation by [protein|search|DegU], not activated by [protein|search|DegU]-P [Pubmed|19416356]
  • [protein|search|SinR]: transcription repression[Pubmed|16923912]
  • [protein|search|ScoC]: transcription repression [Pubmed|16923912]
  • [SW|Spo0A]: prevents repression by [protein|search|SinR] [Pubmed|23660663]

    • Biological materials

    Mutant

  • 1A1021 ( ''epr''::''tet''), [Pubmed|20400548], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1021&Search=1A1021 BGSC]
  • BKE38400 (''ΔaprE::erm trpC2''), available at BGSC
  • KO7 (''ΔnprE ΔaprE Δepr Δmpr ΔnprB Δvpr Δbpr''), available as BGSC 1A1133

    • References

    Reviews

  • 20735481

    • Original publications

  • 16923912,3142851,19416356,18957862,19416356,11751842,23660663,24115457