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polY2 [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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polY2 [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

translesion synthesis (TLS-) DNA polymerase Y2
locus
BSU23710
pI
9.53
mw
45.00 kDa
function
UV-targeted mutagenesis
product
translesion synthesis (TLS-) DNA polymerase Y2
essential
no
synonyms
yqjW

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA repair/ recombination]
  • This gene is a member of the following [SW|regulons]

  • [SW|LexA regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,464,562 -> 2,465,800

    The protein

    Catalyzed reaction/ biological activity

  • Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
  • Protein family

  • DNA polymerase type-Y family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [SW|PolY1], [protein|search|UvrX], [protein|search|YozK]-[protein|search|YobH]
  • [SW|Interactions]

  • [SW|PolY2]-[protein|search|DnaN] (required for untargeted mutagenesis) [Pubmed|15469515]
  • [protein|search|PolA]-[SW|PolY2] [Pubmed|16045613]
  • Expression and Regulation

    Operon

  • ''[SW|polY2]-[protein|search|yqjX]'' (according to [http://dbtbs.hgc.jp/COG/prom/yqjWX.html DBTBS])
  • Regulation

  • induced upon DNA damage ([protein|search|LexA]) [Pubmed|15469515,16267290]
  • Regulatory mechanism

  • [protein|search|LexA]: transcription repression [Pubmed|15469515,16267290]
  • Biological materials

    Mutant

  • GP1505 (''polY2''::''kan''), available in [SW|Stülke] lab
  • References

    Reviews

  • 22933559
  • Original publications

  • 16267290,12644484,15469515,16045613,19924481,23686288