GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
function
riboflavin biosynthesis
product
GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.2|Biosynthesis/ acquisition of riboflavin/ FAD][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]This gene is a member of the following [SW|regulons]
[SW|FMN-box]The protein
Catalyzed reaction/ biological activity
D-ribulose 5-phosphate = formate L-3,4-dihydroxybutan-2-one 4-phosphate (according to Swiss-Prot)Structure
[PDB|2BZ0] (from ''E. coli'', 54% identity, 69% similarity to the C-terminal domain) [Pubmed|16115872]Expression and Regulation
Operon
''[protein|search|ribD]-[protein|search|ribE]-[protein|search|ribA]-[protein|search|ribH]-[protein|search|ribT]'' [Pubmed|8159171][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8159171]Regulation
expressed in the absence of FMN ([protein|search|FMN-box]) [Pubmed|15808508]Regulatory mechanism
[protein|search|FMN-box]: [SW|riboswitch], mediates termination/ antitermination control of the operon, in the absence of FMN: antitermination, in the presence of FMN: termination [Pubmed|15808508]References
19583770,12456892,15808508,8159171,7934829,7934830,16115872,23270261,24442413,26280801 
