SubtiBank SubtiBank
ribA [Sun Oct 25 2015 18:14:12 GMT+0100 (CET)]
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ribA [Sun Oct 25 2015 18:14:12 GMT+0100 (CET)]

GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
locus
BSU23260
pI
5.00
mw
43.00 kDa
function
riboflavin biosynthesis
product
GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
essential
no
ec
3.5.4.25
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.2|Biosynthesis/ acquisition of riboflavin/ FAD]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]
  • This gene is a member of the following [SW|regulons]

  • [SW|FMN-box]
  • The protein

    Catalyzed reaction/ biological activity

  • D-ribulose 5-phosphate = formate L-3,4-dihydroxybutan-2-one 4-phosphate (according to Swiss-Prot)
  • Structure

  • [PDB|2BZ0] (from ''E. coli'', 54% identity, 69% similarity to the C-terminal domain) [Pubmed|16115872]
  • Expression and Regulation

    Operon

  • ''[protein|search|ribD]-[protein|search|ribE]-[protein|search|ribA]-[protein|search|ribH]-[protein|search|ribT]'' [Pubmed|8159171]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8159171]
  • Regulation

  • expressed in the absence of FMN ([protein|search|FMN-box]) [Pubmed|15808508]
  • Regulatory mechanism

  • [protein|search|FMN-box]: [SW|riboswitch], mediates termination/ antitermination control of the operon, in the absence of FMN: antitermination, in the presence of FMN: termination [Pubmed|15808508]
  • References

  • 19583770,12456892,15808508,8159171,7934829,7934830,16115872,23270261,24442413,26280801