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ribA [2019-07-04 13:30:38]
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ribA [2019-07-04 13:30:38]

GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
locus
BSU23260
pI
5.58
mw
43.96 kDa
protein length
398 aa Sequence Blast
gene length
1197 bp Sequence Blast
function
riboflavin biosynthesis
product
GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase
essential
no
ec
3.5.4.25
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.2|Biosynthesis/ acquisition of riboflavin/ FAD]

    • Gene

    Coordinates
    2,428,389 → 2,429,585

    The protein

    Catalyzed reaction/ biological activity

  • D-ribulose 5-phosphate = formate L-3,4-dihydroxybutan-2-one 4-phosphate (according to Swiss-Prot)

    • Structure

  • [PDB|2BZ0] (from ''E. coli'', 54% identity, 69% similarity to the C-terminal domain) [Pubmed|16115872]

    • Biological materials

    Mutant

  • BKE23260 (Δ[gene|F07B7062C850106A95C15978E36DA500F8B089D6|ribA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATGAAACATGCAAATCTTCC, downstream forward: _UP4_TAATCACAAATATCACAAAA
  • BKK23260 (Δ[gene|F07B7062C850106A95C15978E36DA500F8B089D6|ribA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATGAAACATGCAAATCTTCC, downstream forward: _UP4_TAATCACAAATATCACAAAA

    • References

  • 19583770,12456892,15808508,8159171,7934829,7934830,16115872,23270261,24442413,26280801,26494285