non-specific DNA-binding protein Hbsu
function
DNA packaging, function of the signal recognition complex
product
non-specific DNA-binding protein Hbsu
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]Gene
Coordinates
2,385,543 → 2,385,821
Phenotypes of a mutant
essential [Pubmed|12682299,1382620]The protein
Catalyzed reaction/ biological activity
[protein|EFD8FC875B6787B1512C5FC4C81E7E4C9BD93028|Hbs]-mediated untwisting of the DNA stimulates [protein|C352560155F5B2E951B5059794D7B319C1A3AF2C|Nth] endonuclease activity at AP sites [Pubmed|21954439]Protein family
DbpA subfamily (according to Swiss-Prot)Paralogous protein(s)
[protein|3FFFA28E2C16508C6A94408B739864DB7F8DD1F7|YonN] Modification
phosphorylated on Arg-61 [Pubmed|22517742]phosphorylation on Thr-4 [Pubmed|17218307]Structure
[PDB|1HUU] (Geobacillus stearothermophilus)[SW|Localization]
associated with the nucleoid in vegetative cells and forespores [Pubmed|9068655,10715001]membrane associated [Pubmed|18763711]Biological materials
two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Fabian Commichau]'s lablabs
[SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage][SW|Mohamed Marahiel], University of Marburg, Germany [http://www.uni-marburg.de/fb15/ag-marahiel/Prof.%20Dr.%20Mohamed%20A.%20Marahiel Homepage]References
Reviews
Original publications
1382620,1902464,10715001,9068655,9894920,16267290,19458035,19210617,18763711,17218307,21954439,22517742,23033921,10231583,8748031,7852372,9106208,28977557