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parB [Sun Feb 19 2017 11:49:03 GMT+0100 (CET)]
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parB [Sun Feb 19 2017 11:49:03 GMT+0100 (CET)]

chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication
locus
BSU40960
pI
8.00
mw
32.00 kDa
function
chromosome positioning before asymmetric septation,
product
centromer-binding protein
essential
no
synonyms
spo0J, spo0JB

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|sporulation/ other]
  • This gene is a member of the following [SW|regulons]

  • [SW|Spo0A regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    4,205,556 -> 4,206,404

    The protein

    Catalyzed reaction/ biological activity

  • inhibits [protein|search|ParA] dimerization and concomitant DNA-binding activity by stimulating [protein|search|ParA] ATPase activity [Pubmed|21235642]
  • recruits the condensin complex to the DNA origin region [Pubmed|24440393]
  • the dimer binds specifcally to the centromere-like ''parS'' sequence [Pubmed|25572315]
  • Protein family

  • parB family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|Noc]
  • Structure

  • [PDB|4UMK] (complex with ''parS'' DNA)
  • [SW|Localization]

  • chromosome centromer [Pubmed|23475963]
  • [SW|Interactions]

  • forms dimers [Pubmed|24829297]
  • [protein|search|ParA]-[protein|search|ParB] [Pubmed|21235642]
  • Expression and Regulation

    Operon

  • ''[protein|search|parA]-[protein|search|parB]'' [Pubmed|22383849]
  • Regulation

  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
  • Regulatory mechanism

  • [SW|Spo0A]: transcription repression [Pubmed|14651647]
  • Biological materials

    Mutant

  • 1S135 ( ''spo0J''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S135&Search=1S135 BGSC]
  • 1S136 ( ''spo0J''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S136&Search=1S136 BGSC]
  • 1S137 ( ''spo0J''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S137&Search=1S137 BGSC]
  • Labs working on this gene/protein

  • [SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]
  • References

    Reviews

  • 22934648,26706151,28075389
  • Original publications

  • 17462018,16677298,12562803,10852876,10482533,9506522,8071208,17932079,19450517,21235642,26253537,9663676,11532141,19450516,15659156,18854156,9159397,8866474,9778525,16925562,1900505,9364919,9701805,12950914,14651647,19450517,19450516,14563866,23475963,21911367,24440393,24829297,24696501,25071173,25572315,25951515,26295962,28154080