SubtiBank SubtiBank
fhuG [2017-8-11 16:0:3]
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fhuG [2017-8-11 16:0:3]

hydroxamate siderophore ABC transporter (ferrichrome und ferrioxamine) (permease)
locus
BSU33300
pI
10.20
mw
36.00 kDa
protein length
336 aa Sequence Blast
gene length
1008 bp Sequence Blast
function
siderophore uptake
product
hydroxamate siderophore ABC transporter (ferrichrome und ferrioxamine) (permease)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,416,212 → 3,417,222

    The protein

    Protein family

  • FecCD subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|34A7E22B4EF118EF5A76F8CC2DABBB023BC9A2E9|YfhA], [protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|FecE]

    • Structure

  • [PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuC shares 33% identity, 67% similarity with FhuG, [Pubmed|25402482]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]-[gene|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG]-[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]

    description

  • [pubmed|22383849]

    • regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

    • regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393,12354229]
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    References

  • 10092453,16672620,25402482,12354229