SubtiBank SubtiBank
rpsO [Mon Oct 10 2016 19:50:54 GMT+0200 (CEST)]
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rpsO [Mon Oct 10 2016 19:50:54 GMT+0200 (CEST)]

ribosomal protein
locus
BSU16680
pI
10.00
mw
10.00 kDa
function
translation
product
ribosomal protein S15 (BS18)
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,738,941 -> 1,739,210

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]
  • The protein

    Protein family

  • [SW|ribosomal protein] S15P family (according to Swiss-Prot)
  • Structure

  • [PDB|1A32] (''Geobacillus stearothermophilus'')
  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]
  • [SW|Interactions]

  • [SW|23S rRNA]-[rpsO|search|S15] [Pubmed|10497132]
  • [SW|16S rRNA]-[rpsO|search|S15] [Pubmed|11846555]
  • Expression and Regulation

    Operon

  • ''rpsO'' [Pubmed|19633085]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • translational repression of ''rpsO'' expression upon binding of excess [protein|search|RpsO] to a [SW|RNA switch] in the untranslated region of the ''rpsO'' mRNA [Pubmed|23611891,16005889]
  • Additional information

  • the mRNA is processed, this is initiated by [rny|search|RNase Y] and cleavage products are subsequently subject to exonucleolytic degradation by RNases [rnjA|search|J1] and [rnjB|search|J2] and by [pnpA|search|PNPase] [PubMed|20418391]
  • References

  • 19633085,19653700,20418391,10497132,11846555,23002217,16005889,23611891,25903689