SubtiBank SubtiBank
rpsO
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rpsO

ribosomal protein
locus
BSU_16680
pI
10.00
mw
10.00 kDa
protein length
gene length
270 bp Sequence Blast
function
translation
product
ribosomal protein S15 (BS18)
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    1,738,941 → 1,739,210

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]
  • The protein

    Protein family

  • universal [SW|ribosomal protein] uS15 family (single member, according to UniProt)
  • Structure

  • [PDB|1A32] (''Geobacillus stearothermophilus'')
  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]
  • Expression and Regulation

    Operons

    genes
    [gene|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO]
    description
    [Pubmed|19633085]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • regulation

  • translational repression of ''rpsO'' expression upon binding of excess [protein|EC5D3ECF361C7CDEB606284F5E17243CD926989E|RpsO] to a [SW|RNA switch] in the untranslated region of the ''rpsO'' mRNA [Pubmed|23611891,16005889]
  • additional information

  • the mRNA is processed, this is initiated by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] and cleavage products are subsequently subject to exonucleolytic degradation by RNases [protein|3EB289D0F58A58C693AB588798EE66A731341999|J1] and [protein|B73CE26E7AEFACFA82C67F3E7DBBB3F766F739CA|J2] and by [protein|64C6D783FF3F41C81B216F798A1DC8071345B1ED|PNPase] [PubMed|20418391]
  • the [SW|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
  • view in new tab

    genes
    [gene|85E732993186528CF58FECFFE89C8F39D278F28D|ribC]-[gene|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO]
    description
    [Pubmed|22383849]
    view in new tab

    References

  • 19633085,19653700,20418391,10497132,11846555,23002217,16005889,23611891,25903689,27580716,29794222