tcyP [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

cystine transporter, membrane protein

locus: BSU09130

pI: 9.00

mw: 48.00 kDa

function: cystine uptake

product: cystine transporter, membrane protein

essential: no

synonyms: yhcL

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.6|Dicarboxylate/amino acid:cation symporter]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|CymR regulon]

Gene

Coordinates on the chromosome (coding sequence): 986,986 -> 988,377

The protein

Catalyzed reaction/ biological activity

• cystine-proton symporter [Pubmed|15262924]

Kinetic information

• K(m) = 0.6 myM [Pubmed|15262924]

Structure

• [PDB|3KBC] (from ''Pyrococcus horikoshii'', 28% identity) [Pubmed|19924125]

[SW|Localization]

• membrane associated [Pubmed|18763711]

Expression and Regulation

Operon

• ''tcyP

Regulation

• repressed in the presence of sulfate or cysteine ([protein|search|CymR]) [Pubmed|16513748]

Regulatory mechanism

• [protein|search|CymR]: transcription repression [Pubmed|16513748]

Biological materials

Mutant

• 1A949 ( ''tcyP''::''spec''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A949&Search=1A949 BGSC]

Labs working on this gene/protein

• [[Isabelle Martin-Verstraete]], Institute Pasteur, Paris, France

References

• 15262924,12193636,16513748,16513748,18763711,19924125