dxs [Mon Nov 21 2016 12:40:24 GMT+0100 (CET)]

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis

locus: BSU24270

pI: 6.00

mw: 69.00 kDa

function: biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis

product: 1-deoxyxylulose-5-phosphate synthase

essential: yes

ec: 2.2.1.7

synonyms: yqiE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|biosynthesis of cofactors], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|stringent response]

Gene

Coordinates on the chromosome (coding sequence): 2,523,713 -> 2,525,614

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Pyruvate D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate CO₂ (according to Swiss-Prot)

Protein family

• DXPS subfamily (according to Swiss-Prot)

Structure

• [http://www.proteopedia.org/wiki/index.php/2o1s 2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]

Expression and Regulation

Regulation

• [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

Reviews

• 19348578

Original publications

• 12882400,17135236,21296950,23840410