SubtiBank SubtiBank
dxs
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dxs

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis
locus
BSU24270
pI
6.00
mw
69.38 kDa
protein length
633 aa Sequence Blast
gene length
1899 bp Sequence Blast
function
biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis
product
1-deoxyxylulose-5-phosphate synthase
essential
yes
ec
2.2.1.7
synonyms
yqiE

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,523,713 → 2,525,614

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2 (according to Swiss-Prot)
  • Protein family

  • DXPS subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]
  • Expression and Regulation

    Operons

    genes
    [gene|EA9FCF84AE4FA80993566B62A9200D4B32AF5670|dxs]-[gene|923C4177500E9678A0B4855F8F481D4A36ECD863|yqxC]-[gene|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC]-[gene|5680A06A74D3EC6310EF8677795511C75DB3059E|recN]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]
  • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
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    References

    Reviews

  • 19348578
  • Original publications

  • 12882400,17135236,21296950,23840410,27856234