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dxs
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dxs

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis
locus
BSU_24270
pI
6.00
mw
69.38 kDa
protein length
633 aa Sequence Blast
gene length
1902 bp Sequence Blast
function
biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis
product
1-deoxyxylulose-5-phosphate synthase
essential
yes
ec
2.2.1.7
synonyms
yqiE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    2,523,713 → 2,525,614

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • D-glyceraldehyde 3-phosphate + H+ + pyruvate --> 1-deoxy-D-xylulose 5-phosphate + CO2 (according to UniProt)

    • Protein family

  • transketolase family (with [protein|000E237B00539E6850B6A50EE01BA02844B6ACBC|Tkt], according to UniProt)

    • Structure

  • [PDB|2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]

    • References

    Reviews

  • 19348578

    • Original publications

  • 12882400,17135236,21296950,23840410,27856234