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21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
tsaC [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
L-threonylcarbamoyl-AMP synthase, biosynthesis of the hypermodified base threonylcarbamoyladenosine (t(6)A) (together with TsaB-TsaD-TsaE)
categories[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 220.127.116.11|tRNA modification and maturation]
[SW|Categories] containing this gene/protein[SW|translation]
This gene is a member of the following [SW|regulons][SW|DnaA regulon]
Coordinates on the chromosome (coding sequence)
3,792,969 -> 3,794,009
Phenotypes of a mutantrestores viability of a ''[SW|smc]'' mutant on rich medium due to the induction of a [SW|stringent response] [Pubmed|26539825]
Catalyzed reaction/ biological activityconversion of L-threonine, bicarbonate/CO2 and ATP to give the intermediate L-threonylcarbamoyl-AMP (TC-AMP) and pyrophosphate as products [Pubmed|23072323]biosynthesis of the hypermodified base threonylcarbamoyladenosine (t(6)A), a universal modification found at position 37 of ANN decoding tRNAs, which imparts a unique structure to the anticodon loop enhancing its binding to ribosomes in vitro (shown for the corresponding ''E. coli'' protein YrdC) [Pubmed|19287007]
Protein familySUA5 family (according to Swiss-Prot)
Structure[PDB|1HRU] (the homolog from ''E. coli'') [Pubmed|19287007]
Expression and Regulation
Operon'' [protein|search|tsaC]'' [Pubmed|22383849]
Regulatory mechanism[protein|search|DnaA]: transcription repression [Pubmed|17932079]