mrpA

Na⁺ transporter subunit of the Na⁺/H⁺ antiporter, multiple resistance and pH homeostasis

Locus: BSU_31600

Isoelectric point: 9.52

Molecular weight: 86.23 kDa

Protein length: 774 aa

Gene length: 2325 bp

Function: sodium export

Product: Na⁺/H⁺ antiporter subunit

Essential: yes

Synonyms: yufT,shaA,ntrA

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → Transporters/ other → Metal ion transporter
• Cellular processes → Homeostasis → Metal ion homeostasis (K, Na, Ca, Mg) → Sodium uptake/ export
• Groups of genes → Essential genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 3,246,679 → 3,249,003

Phenotypes of a mutant

• essential PubMed
• a mrpA mutant is viable at pH7.4 and sodium concentrations below 80 mM PubMed
• the mrpA mutant accumulates internal sodium PubMed

The protein

Catalyzed reaction/ biological activity

• Na transporter subunit of the Na /H antiporter PubMed

Protein family

• CPA3 antiporters (TC 2.A.63) subunit A family (single member, according to UniProt)

Structure

• 4HE8 (from Thermus thermophilus, 36% identity in a 57% fragment) PubMed

Localization

• inner spore membrane PubMed

Expression and Regulation

Operons

• Genes: mrpA-mrpB-mrpC-mrpD-mrpE-mrpF-mrpG
  Description: PubMed

Biological materials

Mutant

• MGNA-B557 (yufT::erm), available at the NBRP B. subtilis, Japan

References

Reviews

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Original publications

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