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sivA [2017-8-11 16:0:3]
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sivA [2017-8-11 16:0:3]

inhibitor of [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|KinA] autophosphorylation, and subsequently of entry into [SW|sporulation]
locus
BSU37800
pI
7.18
mw
16.55 kDa
protein length
154 aa Sequence Blast
gene length
462 bp Sequence Blast
function
control of entry into [SW|sporulation] via the [SW|phosphorelay]
product
inhibitor of [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|KinA] autophosphorylation
essential
no
synonyms
yweA,ipa-74d
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.2|Proteins controlling the activity of the kinases]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.2|Proteins controlling the activity of the kinases]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • Gene

    Coordinates
    3,882,191 → 3,882,655

    Phenotypes of a mutant

  • the'' [gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA] [gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]'' double mutant exhibits a more severe loss of repellency of the biofilm surface as compared to the ''[gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]'' mutant [Pubmed|22571672]

    • The protein

    Catalyzed reaction/ biological activity

  • inhibits [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|KinA] autophophorylation [Pubmed|23335417]

    • Paralogous protein(s)

  • [protein|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|BslA]

    • Structure

  • [PDB|5MKD]

    • [SW|Localization]

  • membrane (according to Swiss-Prot)
  • extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operons

    genes
    [gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA]
    description
    [Pubmed|12823818]

    regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
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    Biological materials

    Mutant

  • MGNA-B238 (yweA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1237 NBRP B. subtilis, Japan]

    • References

  • 18957862,12823818,22571672,23335417,20817675,28698374,28751732