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yweA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
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yweA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

inhibitor of KinA autophosphorylation, and subsequently of entry into sporulation
locus
BSU37800
pI
7.18
mw
16.00 kDa
function
control of entry into sporulation via the phosphorelay
product
inhibitor of KinA autophosphorylation
essential
no
synonyms
ipa-74d

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.2|Proteins controlling the activity of the kinases]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.2|Proteins controlling the activity of the kinases]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|phosphorelay]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,882,191 -> 3,882,655

    Phenotypes of a mutant

  • the'' [protein|search|sivA] [protein|search|bslA]'' double mutant exhibits a more severe loss of repellency of the biofilm surface as compared to the ''[protein|search|bslA]'' mutant [Pubmed|22571672]
  • The protein

    Catalyzed reaction/ biological activity

  • inhibits [protein|search|KinA] autophophorylation [Pubmed|23335417]
  • Paralogous protein(s)

  • [protein|search|BslA]
  • [SW|Localization]

  • membrane (according to Swiss-Prot)
  • extracellular (signal peptide) [Pubmed|18957862]
  • Expression and Regulation

    Operon

  • ''sivA'' [Pubmed|12823818]
  • Regulatory mechanism

  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]
  • References

  • 18957862,12823818,22571672,23335417,20817675