product
cysteine-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys) (according to Swiss-Prot)Protein family
class-I aminoacyl-tRNA synthetase family (according to Swiss-Prot)Modification
phosphorylation on Ser-270 [Pubmed|17218307]Structure
[PDB|1U0B] (from ''Escherichia coli'', 42% identity, 56% similarity) [Pubmed|15489861][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|gltX]-[protein|search|cysE]-[protein|search|cysS]-[protein|search|mrnC]-[protein|search|yacO]-[protein|search|yacP]'' [Pubmed|7510287][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7510287]Regulation
repression by cysteine ([protein|search|T-box]) [Pubmed|7510287]Regulatory mechanism
[protein|search|T-box], overlaps a transcription terminator upstream of ''[protein|search|cysE]'': transcription antitermination [Pubmed|7510287]References
19258532,17218307,7510287 
