dihydroorotic acid dehydrogenase (catalytic subunit)
function
pyrimidine biosynthesis
product
dihydroorotic acid dehydrogenase (catalytic subunit)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides]This gene is a member of the following [SW|regulons]
[SW|PyrR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,627,718 -> 1,628,653
The protein
Catalyzed reaction/ biological activity
(S)-dihydroorotate O2 = orotate H2O2 (according to Swiss-Prot) Protein family
Type 1 subfamily (according to Swiss-Prot)Structure
[PDB|1EP1] (from ''Lactococcus lactis'', 68% identity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1709162]Regulation
induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]Regulatory mechanism
[protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]Biological materials
Mutant
1A806 ( ''pyrD''::''cat''), [Pubmed|15109830], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A806&Search=1A806 BGSC]1A807 ( ''pyrD''::''kan''), [Pubmed|15109830], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A807&Search=1A807 BGSC]References
