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mcpB [Sun Dec 04 2016 12:51:33 GMT+0100 (CET)]
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mcpB [Sun Dec 04 2016 12:51:33 GMT+0100 (CET)]

membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein, receptor for asparagine
locus
BSU31260
pI
5.00
mw
71.00 kDa
function
control of chemotaxis
product
methyl-accepting chemotaxis protein
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.4|Membrane-bound chemoreceptors]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|motility and chemotaxis], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigD regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,210,445 -> 3,212,433

    The protein

    Paralogous protein(s)

  • [protein|search|McpA]
  • Kinetic information

  • K(D) for asparagine: 14 myM [Pubmed|19864420]
  • Modification

  • methylated at residues Gln371, Glu630, and Glu637 [Pubmed|20864474]
  • Effectors of protein activity

  • asparagine (binds to the part of McpB that is exposed to the exterior) [Pubmed|19864420]
  • [SW|Localization]

  • cell membrane [Pubmed|18763711,21515776]
  • localized at the cell poles, but in the presence of high asparagine concentration there is a reversible re-localization to the sides of the cell (lateral clusters) [Pubmed|21098025]
  • [SW|Interactions]

  • [protein|search|CheA]-[protein|search|McpB] [Pubmed|19864420]
  • [protein|search|McpB]-[protein|search|CheC] [Pubmed|11722727]
  • [protein|search|McpB]-[protein|search|CheW] [Pubmed|25039821]
  • [protein|search|McpB]-[protein|search|CheD] to increase the ability of [protein|search|McpB] to activate [protein|search|CheA] [Pubmed|25039821]
  • Expression and Regulation

    Operon

  • ''[protein|search|mcpB]'' [Pubmed|8188684]
  • [SW|Sigma factor]

  • [protein|search|SigD] [Pubmed|8188684]
  • Additional information

  • in minimal medium, McpB is present with 6,200 /- 1,900 molecules per cell [PubMed|21515776]
  • References

  • 11722727,10825179,8251536,12909020,10196193,15544802,6137212,9194713,2505839,8188684,2105313,12123464,14731274,20864474,18763711,19864420,21098025,21515776,25039821