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hemH [Wed Jan 20 2016 14:31:04 GMT+0100 (CET)]
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hemH [Wed Jan 20 2016 14:31:04 GMT+0100 (CET)]

ferrochelatase, catalyzes the final step of heme b biosynthesis
locus
BSU10130
pI
4.00
mw
35.00 kDa
function
heme biosynthesis
product
ferrochelatase
essential
no
synonyms
hemF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,087,250 -> 1,088,182

    The protein

    Catalyzed reaction/ biological activity

  • insertion of Fe(2) into protoporphyrin IX

    • Protein family

  • ferrochelatase family (according to Swiss-Prot)

    • Structure

  • [PDB|2HK6] (complex with iron), [PDB|1AK1]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • ([protein|search|Fra])-[protein|search|HemH], requires iron, Kd of 1.63 ± 0.02 μM [Pubmed|25826316]

    • Expression and Regulation

    Operon

  • ''[protein|search|hemE]-[protein|search|hemH]-[protein|search|hemY]'' [Pubmed|1459957]

    • References

  • 9384565,1459957,8119288,21052751,23097001,16453119,25826316