SubtiBank SubtiBank
tatAD [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

tatAD [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

component of the TatAD-TatCD twin-arginine translocase
locus
BSU02630
pI
9.00
mw
7.00 kDa
function
TAT protein secretion
product
component of the twin-arginine
translocation pathway
essential
no
synonyms
yczB

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|phosphate metabolism], [SW|protein secretion], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|PhoP regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    285,775 -> 285,987

    The protein

    Catalyzed reaction/ biological activity

  • translocation of [protein|search|PhoD] [Pubmed|19395490]
  • Protein family

  • tatA/E family (according to Swiss-Prot)
  • Structure

  • [PDB|2L16] [Pubmed|20726548]
  • [SW|Localization]

  • membrane (according to Swiss-Prot), forms foci at the division sites and cell poles, localization requires interaction with [SW|TatCD] or [SW|TatCY] [Pubmed|19395490]
  • [SW|Interactions]

  • [SW|TatAD]-[protein|search|PhoD] [Pubmed|12867413]
  • [SW|TatAD]-[SW|TatCD], [SW|TatAD]-[SW|TatCY] [Pubmed|19395490]
  • [protein|search|CsbC]-[SW|TatAD] [Pubmed|23180473]
  • [SW|TatAC]-[SW|TatAD] [Pubmed|23180473]
  • [SW|TatAY]-[SW|TatAD] [Pubmed|23180473]
  • Expression and Regulation

    Operon

  • ''[protein|search|phoD]-[SW|tatAD]-[SW|tatCD]'' [Pubmed|22383849]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|10094677]
  • Regulation

  • expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|11007775]
  • Regulatory mechanism

  • [protein|search|PhoP]: transcription activation [Pubmed|11007775]
  • Additional information

  • expression of the operon depends on functional [protein|search|HemAT] and [protein|search|CsbC] [PubMed|23180473]
  • Labs working on this gene/protein

  • [SW|Oscar Kuipers], University of Groningen, The Netherlands
  • [http://molgen.biol.rug.nl/molgen/index.php Homepage]
  • References

    Reviews

  • 22683878,24140208,25975269,25494301
  • Original publications

  • 12867413,15554971,20726548,11007775,19395490,21479178,21479530,22383849,10094677,23180473,23567937,20977272