component of the TatAD-TatCD twin-arginine translocase
function
TAT protein secretion
product
component of the twin-arginine
translocation pathway
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|phosphate metabolism], [SW|protein secretion], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|PhoP regulon]Gene
Coordinates on the chromosome (coding sequence)
285,775 -> 285,987
The protein
Catalyzed reaction/ biological activity
translocation of [protein|search|PhoD] [Pubmed|19395490]Protein family
tatA/E family (according to Swiss-Prot)Structure
[PDB|2L16] [Pubmed|20726548][SW|Localization]
membrane (according to Swiss-Prot), forms foci at the division sites and cell poles, localization requires interaction with [SW|TatCD] or [SW|TatCY] [Pubmed|19395490][SW|Interactions]
[SW|TatAD]-[protein|search|PhoD] [Pubmed|12867413][SW|TatAD]-[SW|TatCD], [SW|TatAD]-[SW|TatCY] [Pubmed|19395490][protein|search|CsbC]-[SW|TatAD] [Pubmed|23180473][SW|TatAC]-[SW|TatAD] [Pubmed|23180473][SW|TatAY]-[SW|TatAD] [Pubmed|23180473]Expression and Regulation
Operon
''[protein|search|phoD]-[SW|tatAD]-[SW|tatCD]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10094677]Regulation
expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|11007775]Regulatory mechanism
[protein|search|PhoP]: transcription activation [Pubmed|11007775]Additional information
expression of the operon depends on functional [protein|search|HemAT] and [protein|search|CsbC] [PubMed|23180473]Labs working on this gene/protein
[SW|Oscar Kuipers], University of Groningen, The Netherlands[http://molgen.biol.rug.nl/molgen/index.php Homepage]References
Reviews
22683878,24140208,25975269,25494301,27121927 Original publications
12867413,15554971,20726548,11007775,19395490,21479178,21479530,22383849,10094677,23180473,23567937,20977272 
