ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system
function
export of toxic peptides
product
bacitracin ABC transporter (permease)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|BceR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,109,397 -> 3,111,337
The protein
Catalyzed reaction/ biological activity
binds bacitracin, KD: 60 nM [Pubmed|25118291]inhibits [protein|search|BceS] autophosphorylation activity in the absence of bacitracin [Pubmed|25118291]Protein family
ABC-4 integral membrane protein family (according to Swiss-Prot)Effectors of protein activity
the activity of the [protein|search|BceA]-[protein|search|BceB] [SW|ABC transporter] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[protein|search|ytpB]'' mutant [Pubmed|24806199][SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|BceA]-[protein|search|BceB] [Pubmed|25118291,23687272][protein|search|BceB]-[protein|search|BceS], in the absence of bacitracin [Pubmed|25118291,23687272,21283517]Expression and Regulation
Operon
''[protein|search|bceA]-[protein|search|bceB]'' [Pubmed|12890034]Regulation
induced in the presence of bacitracin, plectasin, mersacidin and actagardine ([protein|search|BceR]) [Pubmed|12890034]Regulatory mechanism
[protein|search|BceR]: transcription activation [Pubmed|12890034]References
Reviews
Original publications
18394148,17905982,12890034,14651641,10092453,14612242,21283517,20606066,21078927,23687272,25118291,24806199,26199330 
