menD [Mon Aug 31 2015 13:56:25 GMT+0200 (CEST)]

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase

locus: BSU30820

pI: 5.66

mw: 63.00 kDa

function: biosynthesis of menaquinone

product: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
synthase / 2-oxoglutarate decarboxylase

essential: yes

ec: 2.2.1.9

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.8|Biosynthesis of menaquinone]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|essential genes]

Gene

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO₂ (according to Swiss-Prot)

Protein family

• MenD subfamily (according to Swiss-Prot)

[SW|Cofactors]

• thiamine pyrophosphate, divalent metal ion such as Mn(2+)) [Pubmed|20600129]

Structure

• [PDB|2X7J] [Pubmed|20600129]

Expression and Regulation

Operon

• ''[protein|search|menF]-[protein|search|menD]-[protein|search|ytxM]-[protein|search|menB]-[protein|search|menE]-[protein|search|menC]'' [Pubmed|9387221,1629163,8550504]

[SW|Sigma factor]

• [protein|search|SigA]: [Pubmed|8550504]

References

• 9387221,1629163,8550504,20600129