hmp [Mon Aug 31 2015 13:53:51 GMT+0200 (CEST)]

flavohemoglobin, involved in resistance to nitric oxide (NO), essential for long-term survival under anaerobic conditions

locus: BSU13040

pI: 5.71

mw: 44.00 kDa

function: resistance to NO

product: flavohemoglobin

essential: no

synonyms: ykiA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.10|Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]

syns: ykiA

[SW|Categories] containing this gene/protein

• [SW|electron transport/ other], [SW|resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]

This gene is a member of the following [SW|regulons]

• [SW|NsrR regulon], [SW|ResD regulon]

The protein

Catalyzed reaction/ biological activity

• 2 NO + 2 O₂ + NAD(P)H = 2 NO₃^- + NAD(P)⁺ (according to Swiss-Prot)

Protein family

• FAD-binding FR-type domain (according to Swiss-Prot)

Expression and Regulation

Operon

• ''hmp'' [Pubmed|8682784]
• ''[protein|search|hmp]-[protein|search|ykjA]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8682784]

Regulation

• expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]
• induced by nitric oxide under anaerobic conditions ([protein|search|NsrR]) [Pubmed|16885456]

Regulatory mechanism

• [protein|search|ResD]: transcription activation [Pubmed|10972836]
• [protein|search|NsrR]: transcription repression [Pubmed|16885456]

References

• 8682784,15231799,24214949,10972836,16885456,18487332,16923910,22383849