SubtiBank SubtiBank
infC [Mon Aug 31 2015 13:56:10 GMT+0200 (CEST)]

infC [Mon Aug 31 2015 13:56:10 GMT+0200 (CEST)]

translation initiation factor IF-3
locus
BSU28870
pI
10.34
mw
19.00 kDa
function
translation
product
initiation factor IF-3
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|RplT regulon], [SW|stringent response]
  • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • IF-3 family (according to Swiss-Prot)
  • Structure

  • [PDB|1TIF] (N-terminal domain, Geobacillus stearothermophilus), [PDB|1TIG] (C-terminal domain, Geobacillus stearothermophilus)
  • Expression and Regulation

    Operon

  • ''[protein|search|infC]-[protein|search|rpmI]-[protein|search|rplT]-[protein|search|ysdA]'' [Pubmed|17289755]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|17289755]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • Regulatory mechanism

  • binding of [protein|search|RplT] to a [SW|RNA switch] in the ''[protein|search|infC]'' leader region causes transcription termination [Pubmed|17289755]
  • References

  • 17289755,11948165,21843271,7664745,21303765,23584454