phosphoribosylformylglycinamidine synthase
function
purine biosynthesis
product
phosphoribosylformylglycinamidine synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides]This gene is a member of the following [SW|regulons]
[SW|G-box], [SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
702,570 -> 703,253
The protein
Catalyzed reaction/ biological activity
ATP N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide L-glutamine H2O = ADP phosphate 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine L-glutamate (according to Swiss-Prot) Structure
[PDB|3D54] (from ''Thermotoga maritima'', 51% identity) [Pubmed|18597481][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|PurS]-[protein|search|PurQ]-[protein|search|PurL] [Pubmed|15301530]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed] Expression and Regulation
Operon
''[protein|search|purE]-[protein|search|purK]-[protein|search|purB]-[protein|search|purC]-[protein|search|purS]-[protein|search|purQ]-[protein|search|purL]-[protein|search|purF]-[protein|search|purM]-[protein|search|purN]-[protein|search|purH]-[protein|search|purD]'' [Pubmed|3036807][SW|Sigma factor]
[protein|search|SigA] [Pubmed|3036807]Regulation
repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]repressed in the presence of guanine([protein|search|G-box]) [Pubmed|3036807]expression activated by glucose (4.4 fold) [Pubmed|12850135]Regulatory mechanism
[PurR]]: transcription repression [Pubmed|7638212][protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750][protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed] References
15301530,3036807,12923093,7638212,12850135,18597481 
