fadF [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

similar to iron-sulphur-binding reductase

locus: BSU37180

pI: 6.00

mw: 79.00 kDa

function: fatty acid degradation

product: unknown

essential: no

synonyms: ywjF

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|utilization of lipids], [SW|membrane proteins], [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|FadR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,814,382 -> 3,816,499

The protein

[SW|Cofactors]

• contains an iron-sulfur cluster

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|fadF]-[protein|search|acdA]-[protein|search|rpoE]'' [Pubmed|17189250]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|17189250]

Regulation

• repressed in the absence of long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]
• repressed by glucose (5-fold) [Pubmed|12850135]
• strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]

Regulatory mechanism

• [protein|search|FadR]: transcription repression [Pubmed|17189250]

Biological materials

Mutant

• BKE37180 (''[protein|search|fadF]''::''erm'', available in the BGSC, in [SW|Fabian Commichau]'s, and in [SW|Jörg Stülke]'s lab)

References

• 12850135,17189250,23033921