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albA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
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albA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production
locus
BSU37370
pI
6.20
mw
51.00 kDa
function
antilisterial bacteriocin (subtilosin) production
product
radical S-adenosylmethionine enzyme
essential
no
synonyms
ywiA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|ResD regulon], [SW|Rok regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,836,323 -> 3,837,669

    The protein

    Catalyzed reaction/ biological activity

  • catalyzes thioether bond formation in subtilosin A [Pubmed|22366720]
  • [SW|Cofactors]

  • contains two [4Fe-4S] clusters [Pubmed|22366720]
  • Expression and Regulation

    Operon

  • ''[protein|search|sboA]-[protein|search|sboX]-[protein|search|albA]-[protein|search|albB]-[protein|search|albC]-[protein|search|albD]-[protein|search|albE]-[protein|search|albF]-[protein|search|albG]'' [Pubmed|10572140]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|xxxxxx] [Pubmed|10572140]
  • Regulation

  • repressed by [protein|search|Rok] [Pubmed|15743949]
  • expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10809710]
  • repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10572140,17720793 PubMed]
  • Regulatory mechanism

  • [protein|search|Rok]: transcription repression [Pubmed|15743949]
  • [protein|search|ResD]: transcription activation [Pubmed|10809710]
  • [protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10572140,17720793 PubMed]
  • References

  • 10809709,10572140,15743949,10809710,10572140,17720793,17190806