SubtiBank SubtiBank
tyrA [Mon Feb 01 2016 11:08:27 GMT+0100 (CET)]
Save the date! 20th International Conference on Bacilli and Gram-Positive Bacteria. Washington, D.C. July 23-26, 2019.

tyrA [Mon Feb 01 2016 11:08:27 GMT+0100 (CET)]

prephenate dehydrogenase
locus
BSU22610
pI
5.00
mw
41.00 kDa
function
biosynthesis of tyrosine
product
prephenate dehydrogenase
essential
no
ec
1.3.1.12
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|TRAP regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,369,251 -> 2,370,366

    The protein

    Catalyzed reaction/ biological activity

  • Prephenate NAD = 4-hydroxyphenylpyruvate CO2 NADH (according to Swiss-Prot)
  • Protein family

  • HisMQ subfamily (according to Swiss-Prot)
  • Effectors of protein activity

  • subject to feedback inhibtion by tyrosine [Pubmed|4956345]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])
  • ''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|21815947]
  • ''[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|21815947]
  • [SW|Sigma factor]

  • ''[protein|search|trpE]'': [protein|search|SigA] [Pubmed|6436812]
  • Regulation

  • not expressed if tryptophan is available ([MtrB|search|TRAP]) [Pubmed|1551827]
  • Regulatory mechanism

  • [MtrB|search|TRAP]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]
  • Additional information

  • the mRNA of the ''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' operon strongly accumulates upon depletion of [rny|search|RNase Y] [Pubmed|21815947]
  • the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]
  • References

  • 21815947,3106153,4956345,3924737,6436812,1551827,8419914