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oppC [Mon May 30 2016 11:06:39 GMT+0200 (CEST)]
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oppC [Mon May 30 2016 11:06:39 GMT+0200 (CEST)]

oligopeptide ABC transporter (permease)
locus
BSU11450
pI
10.00
mw
33.00 kDa
function
initiation of sporulation, competence development
product
oligopeptide ABC transporter (permease)
essential
no
synonyms
spo0KC

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.3|Uptake of peptides]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|utilization of nitrogen sources other than amino acids], [SW|genetic competence], [SW|phosphorelay], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|ScoC regulon], [SW|TnrA regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,222,533 -> 1,223,450

    The protein

    Catalyzed reaction/ biological activity

  • required for the uptake of quorum sensing peptides such as [protein|search|PhrH] [Pubmed|21908671]
  • Protein family

  • ABC transmembrane type-1 domain (according to Swiss-Prot)
  • [SW|Localization]

  • cell membrane [Pubmed|10092453]
  • [SW|Interactions]

  • ([protein|search|OppD]-[protein|search|OppF])-([protein|search|OppB]-[protein|search|OppC])-[protein|search|OppA] [Pubmed|10092453]
  • Expression and Regulation

    Operon

  • ''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'' [Pubmed|1901616]
  • Regulation

  • expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|12823818]
  • repressed during exponential growth ([protein|search|ScoC]) [Pubmed|10383984]
  • Regulatory mechanism

  • [protein|search|TnrA]: transcription activation [Pubmed|12823818]
  • [protein|search|ScoC]: transcription repression [Pubmed|10383984]
  • [protein|search|CodY]: transcription repression, no derepression occurs, however, in a ''[protein|search|codY]'' mutant, due to increased repression by [protein|search|ScoC] [Pubmed|25966844]
  • Biological materials

    Mutant

  • BP68 (spc) available in [SW|Fabian Commichau]'s lab
  • GP2097 (D(''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'')::''aphA3''), available in [SW|Jörg Stülke]'s lab
  • References

  • 12823818,1901616,10092453,9252573,21908671,12823818,10383984,7997159,25966844,1899858,25755103