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metS
methionyl-tRNA synthetase
product
methionyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]Gene
Coordinates
45,633 → 47,627
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP + L-methionine + tRNAMet --> AMP + diphosphate + L-methionyl-tRNAMet (according to UniProt)Protein family
[SW|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)[SW|Domains]
[SW|tRNA-binding domain] (aa 570-662) (accordinig to UniProt)Modification
phosphorylated on Ser-652 [Pubmed|20509597]Structure
[PDB|1WE0] (from ''Thermus thermophilus hb8 mutant'', 40% identity, 57% similarity) [Pubmed|10673435][SW|Localization]
cytoplasm (according to Swiss-Prot)References
14651647,20509597,27120414,11732605