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wprA [Mon Aug 31 2015 13:53:33 GMT+0200 (CEST)]
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wprA [Mon Aug 31 2015 13:53:33 GMT+0200 (CEST)]

secreted quality control protease
locus
BSU10770
pI
9.58
mw
96.00 kDa
function
protein quality control
product
secreted quality control protease
essential
no
synonyms
yisM

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.1|Protein quality control]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • syns
    yisM

    [SW|Categories] containing this gene/protein

  • [SW|cell wall/ other], [SW|proteolysis]
  • This gene is a member of the following [SW|regulons]

  • [SW|YvrHb regulon], [SW|CcpA regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • important for [SW|TatAY]-[SW|TatCY]-dependent export of [protein|search|YkuE] and [protein|search|YwbN] [Pubmed|23180473]
  • involved in degradation of [protein|search|PrsA], [protein|search|HtrA], and [protein|search|HtrB] [Pubmed|24362423]
  • Protein family

  • peptidase S8 family (according to Swiss-Prot)
  • [SW|Localization]

  • extracellular (signal peptide) [Pubmed|18957862]
  • membrane [Pubmed|18763711]
  • cell wall [Pubmed|23180473]
  • [SW|Interactions]

  • [protein|search|WprA]-[SW|TatAY] [Pubmed|23180473]
  • [protein|search|WprA]-[SW|TatCY] [Pubmed|23180473]
  • Expression and Regulation

    Operon

  • ''[protein|search|wprA]'' [Pubmed|16306698]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|22900538]
  • Regulation

  • repressed by glucose ([protein|search|CcpA]) [Pubmed|22900538]
  • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [Pubmed|22900538]
  • [SW|YvrHb]: transcription activation [Pubmed|16306698]
  • Biological materials

    Mutant

  • 1A1021 ( ''wprA''::''kan''), [Pubmed|20400548], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1021&Search=1A1021 BGSC]
  • References

    Reviews

  • 25212246
  • Original publications

  • 22900538,22923395,23180473,21815947,10075409,11987133,9004506,20525796,18957862,18763711,16306698,9687444,12028417,24362423,24115457