SubtiBank SubtiBank
arsC [Mon Aug 31 2015 13:55:44 GMT+0200 (CEST)]
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arsC [Mon Aug 31 2015 13:55:44 GMT+0200 (CEST)]

arsenate reductase
locus
BSU25780
pI
4.75
mw
15.00 kDa
function
detoxification of arsenate
product
arsenate reductase
essential
no
ec
3.1.3.48
synonyms
yqcM

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.3|Skin element]
  • syns
    yqcM

    [SW|Categories] containing this gene/protein

  • [SW|resistance against toxic metals], [SW|Skin element]
  • This gene is a member of the following [SW|regulons]

  • [SW|ArsR regulon], [SW|SigF regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • Protein tyrosine phosphate + H2O = protein tyrosine + phosphate (according to Swiss-Prot)
  • Protein family

  • ArsC family (according to Swiss-Prot)
  • Structure

  • [PDB|1Z2D] (reduced form), [PDB|1Z2E] (oxidized form), [PDB|2IPA] (TrxA-ArsC-complex) [Pubmed|17303556], [PDB|1JL3]
  • [SW|Interactions]

  • [protein|search|ArsC]-[protein|search|TrxA] [Pubmed|17303556]
  • Expression and Regulation

    Operon

  • ''[protein|search|arsR]-[protein|search|yqcK]-[protein|search|arsB]-[protein|search|arsC]'' [Pubmed|9537360]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9537360], [protein|search|SigF] [Pubmed|16497325]
  • Regulation

  • expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325]
  • expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([protein|search|ArsR]) [Pubmed|9537360]
  • Regulatory mechanism

  • [protein|search|ArsR]: transcription repression [Pubmed|9537360]
  • References

  • 16497325,11679756,9537360,17303556,21258851,25494643