SAVE THE DATE!
21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
hutH [Mon Aug 31 2015 13:57:38 GMT+0200 (CEST)]
categories[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 22.214.171.124|Utilization of histidine]
[SW|Categories] containing this gene/protein[SW|utilization of amino acids]
This gene is a member of the following [SW|regulons][SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]
Catalyzed reaction/ biological activityL-histidine = urocanate + NH3 (according to Swiss-Prot)
Protein familyPAL/histidase family (according to Swiss-Prot)
Structure[PDB|1B8F] (from ''Pseudomonas putida'', 43% identity, 62% similarity) [Pubmed|10220322]
[SW|Localization]cytoplasm (according to Swiss-Prot)
Expression and Regulation
[SW|Sigma factor][protein|search|SigA] [Pubmed|8071225]
Regulationrepressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]induced by histidine ([protein|search|HutP]) [Pubmed|8071225]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]
Regulatory mechanism[protein|search|CcpA]: transcription repression [Pubmed|8071225][protein|search|CodY]: transcription repression [Pubmed|8682780][protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]
MutantGP1114 (spc), available in [SW|Stülke] lab