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csaA [2019-03-31 15:56:59]
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csaA [2019-03-31 15:56:59]

molecular chaperone involved in protein secretion
locus
BSU19040
pI
8.69
mw
11.77 kDa
protein length
110 aa Sequence Blast
gene length
333 bp Sequence Blast
function
protein secretion
product
molecular chaperone
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]

    • Gene

    Coordinates
    2,079,214 → 2,079,546

    Phenotypes of a mutant

  • From unsuccessful trials to knock out the gene it was concluded that ''csaA'' apparently is essential. However, in a conditional mutant (Pspac-''csaA''), depletion of the gene product is not lethal. But secretion of some proteins including [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC] was reported to be affected unter such conditions.[Pubmed|10816431]

    • The protein

    Catalyzed reaction/ biological activity

  • Secretion associated chaperone. Assumed functional analogue of ''E. coli'' SecB

    • Protein family

  • FIG1 subfamily (according to Swiss-Prot)

    • [SW|Domains]

  • CsaA contains a tRNA binding domain.

    • Structure

  • [PDB|2NZO]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Additional information

  • The functional entity of CsaA is the homodimer.

    • Expression and Regulation

    Operons

    genes
    [gene|EDD0C5732E487A7F94684289F59B9130773316C1|yobT]-[gene|BB122C73972ACEA08DE97F95FC9AC249671C86A3|yobS]-[gene|6D9AAA63C4E43D2F80C7A2104BDF4D98A21C3B78|yobR]-[gene|6C67AD722D59671ED7589949690773732A8B845F|yobQ]-[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]
    description
    [pubmed|22383849]
    view in new tab

    genes
    [gene|6D9AAA63C4E43D2F80C7A2104BDF4D98A21C3B78|yobR]-[gene|6C67AD722D59671ED7589949690773732A8B845F|yobQ]-[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]
    description
    [pubmed|22383849]
    view in new tab

    Biological materials

    Mutant

  • Pspac-csaA [Pubmed|10816431]
  • BKE19040 (Δ[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE19040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAATAACTCCTTTTT, downstream forward: _UP4_TAACGCAAAAAAAGACGTTT
  • BKK19040 (Δ[gene|DA4A64BDF322EDE9EECE83AC9D4AAA01D3F16720|csaA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK19040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAATAACTCCTTTTT, downstream forward: _UP4_TAACGCAAAAAAAGACGTTT

    • References

    Reviews

  • 25212246,28724440

    • Original publications

  • 10816431,13129613,17372352,10658654