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bioD [2018-10-26 11:44:16]
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bioD [2018-10-26 11:44:16]

dethiobiotin synthase
Locus
BSU30210
Isoelectric point
6.21
Molecular weight
25.01 kDa
Protein length
231 aa Sequence Blast
Gene length
693 bp Sequence Blast
Function
biosynthesis of biotin
Product
dethiobiotin synthase
Essential
no
E.C.
6.3.3.3
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis/ acquisition of biotin

    • Gene

    Coordinates
    3,091,492 → 3,092,187

    The protein

    Catalyzed reaction/ biological activity

  • ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin (according to Swiss-Prot)

    • Protein family

  • dethiobiotin synthetase family (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    bioW-bioA-bioF-bioD-bioB-bioI-ytbQ
    Description
    PubMed

    Regulatory mechanism

  • BirA: repression, PubMed, in BirA regulon

    • Regulation

  • repressed in the presence of biotin (BirA) PubMed
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    Biological materials

    Mutant

  • BKE30210 (ΔbioD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_AGTTCCCGTCACAAAAAAAC, downstream forward: _UP4_ATGAATCAAGTGGGGGTATG
  • BKK30210 (ΔbioD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_AGTTCCCGTCACAAAAAAAC, downstream forward: _UP4_ATGAATCAAGTGGGGGTATG

    • References

    Reviews
    PubMed==

    Original publications

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