ykuR [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

N-acetyl-diaminopimelate deacetylase

locus: BSU14190

pI: 5.10

mw: 41.00 kDa

function: biosynthesis of lysine and peptidoglycan

product: N-acetyl-diaminopimelate deacetylase

essential: yes

ec: 3.5.1.47

synonyms: dapL

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|biosynthesis/ acquisition of amino acids], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 1,489,753 -> 1,490,877

Phenotypes of a mutant

• essential [Pubmed|24261876,12682299]
• depletion of DapI results in swelling and rounding up of cells prior to lysis [Pubmed|24261876]

The protein

Catalyzed reaction/ biological activity

• N-acetyl-LL-2,6-diaminopimelate + H₂O --> acetate + LL-2,6-diaminopimelate [Pubmed|24261876]

Protein family

• peptidase M20A family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|SndA], [protein|search|SndB], [protein|search|SndC]

[SW|Localization]

• forms uniformly distributed foci in the cytoplasm [Pubmed|24261876]

[SW|Interactions]

• forms dimers [Pubmed|24261876]
• [protein|search|DapI]-[protein|search|MreB] [Pubmed|24261876]

References

• 24261876