SubtiBank SubtiBank
cotH [Mon May 30 2016 18:51:03 GMT+0200 (CEST)]
SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

cotH [Mon May 30 2016 18:51:03 GMT+0200 (CEST)]

protein kinase, required for the assembly of several outer coat proteins
locus
BSU36060
pI
5.00
mw
42.00 kDa
function
protection of CotU and CotC in the mother cell
product
protein kinase
essential
no
synonyms
ywrH

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.8|Not yet assigned]
  • [SW|Categories] containing this gene/protein

  • [SW|protein modification], [SW|sporulation proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|GerE regulon], [SW|SigK regulon], [SW|SigE regulon], [SW|SpoIIID regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,716,009 -> 3,717,097

    Phenotypes of a mutant

  • overexpression of ''cotH'' suppresses the phenotypes of a ''[protein|search|cotE]'' mutant [Pubmed|24086406]
  • reduced [SW|germination] efficiency [Pubmed|27185916]
  • The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation with ATP and subsequent phosphorylation of [SW|CotB] and [SW|CotG] on serine residues [Pubmed|27185916]
  • Protein family

  • cotH family (according to Swiss-Prot)
  • [SW|Cofactors]

  • Mn2 [Pubmed|27185916]
  • Structure

  • [PDB|5JD9] [Pubmed|27185916]
  • [SW|Localization]

  • inner spore coat
  • [SW|Interactions]

  • [protein|search|CotE]-[protein|search|CotH] [Pubmed|26484546]
  • [protein|search|CotB]-[protein|search|CotH] [Pubmed|27185916]
  • [protein|search|CotG]-[protein|search|CotH] [Pubmed|27185916]
  • Expression and Regulation

    Operon

  • ''[protein|search|cotH]-[protein|search|cotB]-[protein|search|ywrJ]'' [Pubmed|22383849]
  • [SW|Sigma factor]

  • [SW|SigE], [protein|search|SigK] [Pubmed|15699190,8755863]
  • Regulation

  • expressed late during sporulation in the mother cell ([SW|SigE], [protein|search|SigK], [protein|search|GerE], [SW|SpoIIID]) [Pubmed|26577401,15699190,8755863,15470121]
  • Regulatory mechanism

  • [protein|search|GerE]: transcription repression [Pubmed|15470121]
  • [protein|search|SpoIIID]: transcription activation [Pubmed|26577401]
  • References

  • 10198031,15699190,8755863,15470121,18065538,24086406,21984783,25259857,25115591,26484546,26953338,27185916,14762006,26577401